N-Mannich Bases of 3,5-Dibromosalicylamide and 3,5-Dichlorosalicylamide: Part II
| Main Authors: | Guru Bachan Singh, G. R. Chawla, V. K. Chhabra, V. K. Vijjan |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1967
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/6519519 |
Daftar Isi:
- In continuation of our work on the\(\propto\)-aminoalkylation of some amide functions1, the N-Mannich bases of 3,5-dibromosalicylamide2 and 3,5-dichlorosalicylamide have been prepared, using some aliphatic and heterocyclic secondary amines. As is expected, the introduction of the halogen atoms in the benzene ring not only facilitates \(\propto\)-aminoalkylation but also, to some extent, favourably affects the therapeutic activity. Infra red absorption spectra of these N-Mannich bases and other chemical evidences establish them as the cerboxamido derivatives. Their mode of formation and mechanism has been discussed. They also behave as Lewis-bases and could he estimated in non-aqueous media.