Cyclisation of Acetoacetanilides and Benzoylacetanilides in presence of Polyphosphoric acid
| Main Authors: | KUSUM DESAI, C. M. DESAI |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1974
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6416666 |
Daftar Isi:
- P. T. S. College of Science, Surat. Manuscript received 5 December 1973; revised 29 April 1974; accepted 29 May 1974 Acetoacetanilides, when heated with PPA at lower temperature, have greater tendency to be cyclised to 2-hydroxyquinolines and at higher temperature to 4-hydroxyquinolines ; whereas benzoylacetanilides get cyclised mostly to 2-hydroxyquinolines at lower temperature, decomposition taking place at higher temperature; thus temperature is a determining factor in the course of cyclisation. Addition of crotonate or arylamine favours formation of 4-hydroxyquinaldines.