Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging
| Main Authors: | Carregal‐Romero, S, Miguel‐Coello, AB, Martínez‐Parra, L, Martí‐Mateo, Y, Hernansanz‐Agustín, P, Fernández‐Afonso, Y, Plaza‐García, S, Gutiérrez, L, Muñoz‐Hernández, MdM, Carrillo‐Romero, J, Piñol‐Cancer, M, Lecante, P, Blasco‐Iturri, Z, Fadón, L, Almansa‐García, AC, Möller, M, Otaegui, D, Enríquez, JA, Groult, H, Ruíz‐Cabello, J. |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2022
|
| Online Access: |
https://zenodo.org/record/6401415 |
Daftar Isi:
- Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost-efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (MnxFe3-xO4, 0.1 <= x <= 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual-mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase-mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications.