Synthesis and CNS Activity of Some Fluorine Containing Pyrazolo[5, 1 -c][1 ,2,4]Triazines
| Main Authors: | KRISHNA C. JOSHI, VIJAI N. PATHAK, URMILA GARG |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1983
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6346242 |
Daftar Isi:
- Organic Chemistry Laboratories, University of Rajasthan, Jaipur-302 004 Manuscript received 27 April 1983, accepted 15 September 1983 Seven new fluorinated pyrazolo[5,1-c][1,2,4] triazines have been synthesized by the condensation of pyrazole diazonium salt with 1,3-diketones in aqueous buffered solution. An intermediate is obtained, which on thermal cyclization in glacial acetic acid, gave pyrazolo[5,1-c][1,2,4] triazines. These compounds have been characterized by ir, pmr, and 19F-nmr spectral studies. Most of the compounds display significant anti-inflammatory activity.