Some Halogenated Sulphonamides with Biological Interest
| Main Authors: | A. M. SH. EL-SHARIEF, Y. A. AMMAR, Y. A. MOHAMED, M. E. A. ZAKI |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1984
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6330752 |
Daftar Isi:
- Chemistry Department, Faculty of Science, Al-Azhar University, Nasr-City, Cairo, Egypt Manuscript received 6 January 1984, accepted 26 May 1984 Various types of sulphonamides derived from 2,5-dichloro- or 2,5-dibromobenzene-sulphonyl chlorides are prepared. Among these are the pyrazoline (IV a-d and X), the isoxazoline (IVe) and the thioxopyrimidine derivatives (Va, b and XI). Secondary amines as thiols add on the sulphonamides (IIa, b) to give (VIa-d and VIIa, b), respectively. Active methylene compounds react with the sulphonamides (IIa, b and III) to give the cyclohexenone derivatives (lXa-d and Xlla, b), respectively. H2O2 on reaction with lIb gives a sulphonamide containing \(\propto\)\(\beta\)-epoxyketone (XV) which react with hydrazines, acetic acid and piperidine to give XVI, XVIIa and XVIIb, respectively. The biological activity of the products against different organisms are discussed.