Hepatoprotective Potential and Antioxidant activities of Ricinus communis against Paracetamol Induced Liver Damage
| Main Authors: | Loveneet Kumar, Najam Ali Khan, Neha Khan, Amit Kumar |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2022
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6327666 |
Daftar Isi:
- The purpose of this study was to determine the hepatoprotective potential of an ethanolic extract of Ricinus communis root (EERC). On rats, the hepatoprotective potential of EERC was evaluated at dosages of 200 and 400 mg/kg (p.o.). The extracts and silymarin-treated animal groups significantly reduced the activities of various biochemical parameters, such as Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Alkaline Phosphatase (ALP), which were elevated by Paracetamol intoxication. Total bilirubin, bilirubin direct, bilirubin indirect, total protein, albumin, and serum globulin levels were also normalized with EERC and silymarin. A dose of 200 mg/kg produced better results than a dose of 400 mg/kg. Treatment with EERC at doses of 200 and 400 mg/kg, p.o. was found to be beneficial in repairing paracetamol-induced hepatotoxicity in rats, according to histological examinations.The antioxidant potential of R. communis root was examined and evaluated using DPPH and H2O2 assays.The purpose of this study was to determine the hepatoprotective potential of an ethanolic extract of Ricinus communis root (EERC). On rats, the hepatoprotective potential of EERC was evaluated at dosages of 200 and 400 mg/kg (p.o.). The extracts and silymarin-treated animal groups significantly reduced the activities of various biochemical parameters, such as Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Alkaline Phosphatase (ALP), which were elevated by Paracetamol intoxication. Total bilirubin, bilirubin direct, bilirubin indirect, total protein, albumin, and serum globulin levels were also normalized with EERC and silymarin. A dose of 200 mg/kg produced better results than a dose of 400 mg/kg. Treatment with EERC at doses of 200 and 400 mg/kg, p.o. was found to be beneficial in repairing paracetamol-induced hepatotoxicity in rats, according to histological examinations.The antioxidant potential of R. communis root was examined and evaluated using DPPH and H2O2 assays.