Synthesis of some New Isonicotinoylazo- pyrazoles
| Main Authors: | RAJEEV JAIN, PRATIBHA PANDEY, NAMRATA JAIN |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1988
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6122470 |
Daftar Isi:
- School of Studies in Chemistry, Jiwaji University, Gwalior-474 011 Manuscript received 30 December 1986, revised 9 November 1987, accepted 5 February 1988 SULPHA drugs are well known for their various physiological activity1-8. Isoniazid is a established antitubercular drug. In the light of the importance of sulpha drugs, isoniazid and considering the biological activity exhibited by azo group, it was considered worthwhile to combine the sulpha drugs with isoniazid through azo group in order to enhance the overall activity of the resulting molecule. N- Isonicotinoyl - 3,5-dimethyl-4- (4'- sulpham oylphenyl) azopyrazoles have been synthesised by diazotising sulphanilamides and coupling the diazotised product with the compounds containing active methylene group, viz. pentane-2,4-dione and 4-phenylaminobutane-2,4-dione, followed by the condensation with isonicotinoylhydrazine.