Mannich Bases of Ethyl 5-Substituted-benzi- midazole-2-thioacetate and their Antiin- flammatory and Analgesic Activities
| Main Authors: | A. V. KASTURE, S. G. WADODKAR, K. P. JAIN |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1988
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6107236 |
Daftar Isi:
- Department of Pharmaceutical Sciences, Nagpur University, Nagpur-440 010 Manuscript received 30 October 1986, accepted 19 February 1988 WIDE range of biological activities1 are reported with various benzimidazole compounds. Some benzimidazole-2-thiones, 1,3-disubstituted benzi-midazole-2-thiones and thioesters are reported to exhibit analgesic and antiinflammatory activities2 The title compounds were thus prepared for evaluating their analgesic and antiinflammatory activity The benzimidazole-2-thiones and their 5-substituted analogues were synthesised by the reation of o-phenylenediamine or 4-substituted-o-phenylenediamine using CS. in presence of ethanolic KOH8. Their corresponding 2-thioacetic acid ethyl ester was prepared using chloroacetic acid, KOH, ethanol and HCl gas. The title compounds (2) were obtained from 1 by reacting with various amines in presence of aqueous 40% formaldehyde solution following standard procedure of Mannich reaction.