Studies in Spiro-heterocycles. Part-XII. Synthesis of some Fluorine containing Spiro[3 H-indole -3,4'( 4H)-pyrano[2,3-d] pyrimidine] - 2,5',7(I H) - triones as CNS Agents
| Main Authors: | KRISHNA C. JOSHI, RENUKA JAIN, KANTI SHARMA |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1988
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6035699 |
Daftar Isi:
- Department of Chemistry, University of Rajasthan, Jaipur-302 004 and S. K, BHATTACHARYA and R. K:, GOEL Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005 Manuscript received 10 July 1987, revised 18 January 1988, accepted 27 January 1988 Several new fluorine containing spiro[3H-indole-3,4'(4H)-pyranol 2,3-d]- pyrimfdine]-2,5',7'(1H)-triones were synthesised by the Michael reaction of 3·(carboethoxycyano/dicyano)methylene-indol-2-ones with barbituric acid; the former being obtained from indole-2,3-dione and malononitrile/ethyl cyanoacetate. The compounds were characterised by ir, pmr, 19F nmr, 12C nmr and mass spectral studies. Representative compounds were tested on mice for CNS activities (analgesic and anticonvulsant) and the effects were also observed against amphetamine induced stereotypy on con- ditioned avoidance response and on potentiation of pentobarbitone sodium hypnosis.