Synthesis of 1 ,2,4-Triazolo(2,3-c]pyrimidin-5(6H)-one Nucleosides and their Antileishmanial Activity
| Main Authors: | KAPTAN SINGH, A. HASAN, RAM PRATAP, P. Y. GURU, D. S BHAKUNI |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1989
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/6024704 |
Daftar Isi:
- Central Drug Research Institute, Lucknow-226 001 6-ß-ᴅ-Ribofuranosyl-s-triazolo(2,3-c]pyrimidin-5(6H)-one (5), 6-ß-ᴅ-xylofuranosyl-s-triazolo [ 2, 3-c ] pyrimidin-5-( 6H )-one (7), 6-(2-hydroxyethoxymethyl)- s-triazolo[2,3-c]pyrimidin-5(6H)-one (9) and 6-[(1,3-dihydroxy-2-propoxy) methyl]-s-triazolo [2,3-c)pyrimidin-5(6H)-one (11) have been synthesised. Compounds 2,5, 7,9 and 11 showed 70,40,65, 0 and 78% inhibition of the growth of amastigotes of Leishmania donovani in hamster at 25 mg/kg dose.