Ferrocene Derivatives. Part-II. Synthesis of some Ferrocenyl[semicarbazone, 1 ,2-benzodiazepines, cyclohexenone, tetrazolopyrimidine and pyrazolopyrimidine] as Antimicrobial Agents
| Main Authors: | MOHAMED ABBAS METWALLY, FATHY A. AMER |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1988
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/6024218 |
Daftar Isi:
- Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt Manuscript received 23 February 1987, revised 28 October 1987, accepted 4 November 1981 Acetylferrocene (1) undergoes condensation with semicarbazido hydrochloride and aromatic aldehydes to give the semicarbazone (2) and the α,β-unsaturated ketones (3). Michael condensation of 3a with cyclohexanone, α.-tetralone, acetophenone and 1,3- diphenylacetone gives the1,5-dicarbonyl compounds (4, 5, 10) and the ferrocenylcyclo- hexenone (11). 1,5-Dicarbonyl compound (4) undergoes condensation with hydrazines to give the 1,2-diazepines (6, 8). Condensation of 3a with 5-aminotetrazole and/or 5-amino-3-phenylpyrazole gives the pyrimidotetrazole (12) and pyrimidopyrazole (13). The structures of the hitherto unknown ring systems have been confirmed by analytical and spectral methods.