Synthesis and Pharmacological Evaluation of some New Substituted-1 ,8-naphthyridines and Substitutedquinazolin-4-ones as Hypotensive and CNS Active Agents
| Main Author: | KANCHAN AGARWAL |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 1991
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5954640 |
Daftar Isi:
- Department of Chemistry, Lucknow University, Lucknow·226 007 Manuscript received 31 May 1990, revised 27 November 1990, accepted 6 December 1990 p-(3 -Aroy1-2-pheny1-1,8-naphthyridinyl)methoxyacetylhydrazine on reaction with isatin converted into 5 and with 2-(3'-nitro-4'-chlorophenyl)quinazolin-4-one converted into 10. Both 5 and 10 on Mannich reaction gave the desired products (7a —j and 11a — f). The compounds were evaluated for central nervous system (CNS) and hypotensive activity.