Dipeptidyl peptidase IV regional and subcellular distribution in goat brain
| Main Authors: | Ashwani Mittal, Shiwani Khurana, Rachna Sadana, Hari Singh, Ramesh C. Kamboj |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2002
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5847681 |
Daftar Isi:
- Department of Biochemistry, Department of Chemistry, Kurukshetra University, Kurukshetra-136 119, India E-mail: bchem@granth.kuk.ernet.in Manuscript received 17 August 2001, accepted 28 January 2002 Dipeptidyl peptidase IV, an important serine proteinase, has been identified in the goat brain tissue. It shows a pH optimum of 7.45 in crude extracts. The regional and subcellular distribution of this proteinase is established in goat brain. The cerebrum portion of the brain has maximum percent activity followed by cerebellum, medulla oblongata, pons-varolli, thalamus, pituitary body and hypothalamus. In terms of activity per gram wet tissue weight, pituitary body is found to have the highest activity. The subcellular localization studies indicate its cytosolic origin in the brain.