Synthesis of 2'-(substituted)benzylidene hydrazino-5-arylamino-1,3,4-thiadiazoles and their antimicrobial activity
| Main Authors: | (Miss) Megha K. Burghate, (Miss) Shital V. Gandhe, (Miss) M. G. Ajmire, B. N. Berad |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2007
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5811829 |
Daftar Isi:
- Several 2' -(substituted) benzylidene hydrazino-S-arIamino-1,3,4-thiadiazoles (5a-m) have been synthesized by the condensation of 1-(N-aryl thioamido)thiocarbohydrazides (3a-f) and different aromatic aldehydes in benzene medium, followed by intramolecular cyclization or compounds (4a-m) in renuxing ethanol medium. The former in turn have been prepared by the reaction of aryl isothiocynates (2a-f) and thiocarbohydrazide (1). Compounds (Sa-m) on bromination with bromine in glacial acetic acid afforded dibromo derivatives (6a-m). The synthesized compounds were assayed for their antimicrobial activity against gram positive as well as gram negative micro-organisms.