Antimicrobial Resistance in Livestock and Food - Its Significance for Human Medicine and Options for Action in Risk Management
Main Author: | German Federal Institute for Risk Assessment |
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Format: | Report |
Terbitan: |
, 2015
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Subjects: | |
Online Access: |
https://zenodo.org/record/581040 |
Daftar Isi:
- Bacteria which are resistant to antimicrobial substances (antibiotics) are widespread. [...] The Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) has evaluated the significance of these resistances in livestock and in food for human consumption. The BfR concludes that the assessment of the contribution made by antimicrobial resistance in livestock that may be transmitted to humans through food to the extent of antimicrobial resistance in human medicine varies according to the bacteria and type of resistance. In the case of multi-resistant Staphylococcus aureus (MRSA) bacteria, the strains originating from animals (livestock-associated MRSA) are currently of minor importance for infections in humans with the exception of people who have frequent contact with livestock (farmers, veterinarians, farm workers. [...] The situation is assessed differently when it comes to ESBL/AmpC-producing strains of bacteria. These resistances severely impair treatment with 3rd and 4th generation cephalosporins, which are used to combat a variety of bacterial infections. The resistant strains of bacteria such as Escherichia coli, Klebsiella and Citrobacter are a cause of concern because the resistance genes are located in mobile genetic elements. They can be easily transferred and recombined among these and other pathogenic bacteria. This transfer is increased with antibiotic treatment. [...] This substantiates previous findings that animals play a role as a source of such bacteria or resistance genes. In addition to direct transfer of the bacteria, the fact that resistance genes can be transferred to other bacteria is of particular importance here. For this reason, only a joint preventive control strategy of veterinary and human medicine (one health approach) against the spread of resistant pathogens can be successful.
- DE; en; efsa-focal-point@bfr.bund.de