Studies on the Biginelli reaction Synthesis of 3,4-dihydropyrimidin-2(1H)-thiones via arylidene intermediate and one pot reaction
| Main Authors: | Nainesh Kansagara, Jagdish Godhasra, Mahesh Patel, Viral Shah |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2009
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5809984 |
Daftar Isi:
- Department of Chemistry, Kamani Science College, Amreli-365 601, Gujarat, India E-mail : naineshkansagara@yahoo.co.in Manuscript received 30 August 2007, revised 5 August 2008, accepted 23 December 2008 The series of 4-aryl-6-isopropyi-5-[N-(3-nitrophenyl)aminocarbonyl]-3,4-dihydropyrimidin-2(1H)-thiones 2a-1 were prepared via arylidene (route-1) intermediates by condensing 2-arylidene-4-methyl-N-(3-nitrophenyl)-3-oxopentanamide and thiourea in the presence of potassium bicarbonate. Then 2a-1 were prepared by single step (route-2) in the presence of cone. HCI catalyst, with better yield in short time compare to route-1. Some of these compounds showed potential antimicrobial activity.