Synthesis and biological study of oxopyrimidines and thiopyrimidines of 2-(2,4-dichlorophenyl)imidazo[1,2-α ]pyridin-3-carbaldehyde
| Main Authors: | M. J. Ladani, S.D. Tala, J.D. Akbari, M. F. Dhaduk, H. S. Joshi |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2009
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5807328 |
Daftar Isi:
- Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India E-mail : drhsjoshi49@gmail.com Manuscript received 14 November 2007, revised 6 August 2008, accepted 17 September 2008 2-(2,4-Dichlorophenyl)lmida7o[1,2-α]pyridlne-3·carbaldehyde (1) was prepared from 2-aminopyridine through multi-step reaction. Compound 1 reacts with different aryl ketones in the presence of catalytic amount of 40% KOH to give (2E)-3-[2-(2,4-dichlorophenyl)imidazo[1,2-α]pyridin-3-yl]-1-arylprop-2-en-1-ones (2a-j), which on cyclization with urea and thiourea in the presence of basic catalyst like KOH afforded 6-[2-(2,4-dichlorophenyl)imidazo[1,2-α]pyridine-3-yl]- 4-aryl-pyrimidin-2(1H)-ones (3a-j) and 6-[2-(2,4-dichlorophenyl)imidazo[1,2-α]pyridine-3-yl]-4-aryl-pyrimidin-2(1H)-thiones (4a-j). The antimicrobial evaluations hale been performed for their antibacterial activity and antifungal activities.