DNA binding/cleavage studies of known hexanuclear/trinuclear copper(n) complexes in presence of standard activators
| Main Authors: | Niraj Kumari, Lallan Mishra |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2012
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5768951 |
Daftar Isi:
- Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221 005, Uttar Pradesh, India E-mail : lmishrabhu@yahoo.co.in Fax : 91-542-2368174 Manuscript received 02 March 2012, accepted 09 March 2012 The polynuclear copper(ll) complexes of types [Cu6Na4(NTA)2(μ-O)2(bpy)6(H2O)4(NO3)2]·3H2O (1) and [Cu3(C2O4)2(bpy)3(H2O)2](NO3)2 (2) (bpy = 2,2'-bipyridyl, H3NTA = nitrilotriacetic acid and C2O42- = oxalate) recently reported by us, have been allowed to interact with calf thymus DNA. Their DNA binding properties are studied using absorption and emission spectral titrations. These complexes cleave supercoiled pBR322 DNA to nicked circular DNA under physiological conditions. Studies using standard radical scavengers suggest the involvement of hydroxyl radicals in the oxidative cleavage of DNA.