Synthesis, characterization and biological activity of metal complexes with 4-aminoantipyrine Schiff bases of 5-chloro salicylaldehyde and 3-ethoxy salicylaldehyde
| Main Authors: | B. Anupama, K. Mounika, M. Sunitha, C. Gyana Kumari, Ch. Venkata Ramana Reddy |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2012
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/5763668 |
Daftar Isi:
- Doepartment of Chemistry, Osmania University, Hyderabad-500 007, India E-mail : prof_c_gyana@yahoo.co.in Department"of Chemistry, JNTUHCE, JNT University, Hyderabad-500 085, India Manuscript received 02 November 2010, revised 12 October 2011, accepted 17 October 2011 A series of transition metal complexes of Cull, NiII, ColI, Znll and VOIV with biological activity, have been synthesized involving the Schiff bases 2,3-dimethyl-1-phenyl-4-(5-chloro-2-hydroxy benzylideneamino)-pyrazol-5-one (S-CI SALAAP), L1 and 2,3-dimethyl-1-phenyl-4-(3-ethoxy-2-hydroxy benzylidcneamino)-pyrazol-5-one (3-0Et SALAAP), L2 derived from 4-amino antipyrine and 5-chloro salicylaldehyde/3-cthoxy salicylaldehyde respectively. Structural features were obtained from their IR, 1H NMR, ESI Mass, UV-Vis, thermo gravimetric studies, elemental analysis, molar conductance and magnetic susceptibility measurements. Molecular modelling studies were also carried out to confirm the geometries of the complexes. The Schiff bases act as tridentate ligands which coordinate through the azomethine nitrogen, phenolic oxygen and carbonyl oxygen of antipyrine ring. The ligands and their metal complexes were screened for their antibacterial activity against Staphylococcus aureus and E. coli. The results showed the metal complexes to be biologically active.