An efficient greener copper triflate-catalyzed C-3 benzylation of 4-hydroxycoumarin and some active methylene compounds
| Main Authors: | Nemai C. Ganguly, Sumanta Chandra |
|---|---|
| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2012
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5761055 |
Daftar Isi:
- Department of Chemistry, University of Kalyani, Kalyani-741 235, West Bengal, India E-mail : nemai_g@yahoo.co.in Manuscript received 19 May 2011, accepted 25 July 2011 4-Hydroxycoumarin has been directly benzylated at C-3 position with a good number of secondary benzylic alcohols using copper triflate catalyst (2 mol%) in toluene under reflux. The protocol provides an efficient, expedient and atom-economic access to warfarin and coumatetralyl analogues with potential anticoagulant activity. The protocol has been extended to benzylation of 4-hydroxy-l-methylquinolin-2(1H)-l-one, N-methylbarbiturate and some other active methylene compounds with remarkable success.