In vitro antifungal activity of some new triazole compounds
| Main Authors: | Sumitra Chanda, Shipra Baluja, Jigna Parekh |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2012
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5759615 |
Daftar Isi:
- Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences, Saurashtra University, Rajkot-360 005, Gujarat, India Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India Manuscript received OJ June 2010, revised 05 May 2011, accepted 20 June 2011 In the present study, the derivatives of 1 ,2,4-triazoles were synthesized and tested for antifungal activity against Candida tropicalis ATCC-4563, Candida albicans ATCC-2091, Cryptococcus neoformans ATCC-34664, Trichos-poron beigelii NCIM-3404 and Aspergillus flavus NCIM-538 by disc diffusion method. 1,2,4-Triazoles were obtained by cyclization of the potassium salt of substituted dithiocarbazinic acid with hydrazine hydrate. The new Synthesized compound~ were characterized using IR, 1H NMR spectral data and Mass spectrometry together with elemental analysis. The inhibitory effect of the newly synthesized triazole compounds was compared to the standard antifungal agents. Minimum inhibitory concentration (MIC) was determined for those compounds which could inhibit all the tested fungal strains with maximum inhibition zone.