Simultaneous determination of paracetamol, pseudoephedrine and diphenhydramine in cold medicines using net analyte signal concept
| Main Authors: | Reza Hajian, Esmat Saleh Kamaei |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2014
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5741737 |
Daftar Isi:
- Young Researchers and Elite Club, Gachsaran Branch, Islamic Azad University, 75818-63876, Gachsaran, Iran E-mail : Hajian@iaug.ac.ir Chemistry Department, Gachsaran Branch, Islamic Azad University, 75818-63876, Gachsaran, Iran Manuscript received online 11 September 2013, revised 30 May 2014, accepted 04 June 2014 In this work a new modification of the standard addition method called Net Analyte Signal Standard Addition Method (NASSAM) was presented for the simultaneous spectrophotometry analysis of paracetamol, pseudoephedrine and diphenhydramine. In this method, the norm of NAS was calculated and correlated to the concentration of analyte by UV-Vis spectrophotometry technique. In this work, pH 8.0 was selected as an optimum parameter for increasing selectivity and omitting some cationic species. The method can be applied for the determination of analytes in the presence of known interferents. The accuracy of the predictions is not dependent on the shape of the analyte and interferent spectra. NASSAM is a simple and sensitive method with high selectivity and low expenses. The detection limits for paracetamol, diphenhydramine and pseudoephedrine have determined as 0.08, 0.08 and 0.22 μmol L–1 with linear dynamic range of 0.2–200, 0.2–200 and 0.5–8000 μmol L–1 respectively. The proposed method has successfully applied to the simultaneous determination of paracetamol, pseudoephedrine and diphenhydramine in cold stop tablets.