Novel synthesis of β-lactams and their biological evaluation
| Main Author: | Bimal K. Banik |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2014
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/5733822 |
Daftar Isi:
- Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, Texas 78539, USA E-mail : bimalbanik10@gmail.com Manuscript received 30 July 2014, accepted 05 August 2014 Stereoselective synthesis of racemic and optically active novel β-lactams using Staudinger cycloaddition reaction with imines and ketenes has been achieved. Microwave induced-reactions have been performed for the preparation of these types of β-lactams and products derived from them. The formation of trans-β-lactams has been rationalized via isomerization of the enolates formed between the reactions of acid chloride (equivalent) with imines in the presence of a tertiary base. A donor-acceptor complex formation has been found to be the intermediate occurred in the formation of cis-β-lactams. A peri hydrogen in the aromatic rings has been proved to be crucial in controlling the isomer distribution of the products. Glycosylation reaction has been performed to prepare a few intermdeaites that are useful for anticancer agents. Cell-growth inhibition study has identified a few β-lactams that demonstrates anticancer activity. Microwave-induced reactions have been conducted for the synthesis of diverse heterocycles using β-lactams as the starting compounds.