Synthesis of dihydropyrimidinones derivatives by Biginelli reaction in basic medium
| Main Authors: | Nivedita Srivastava, Arti Mehrotra, Anil Kumar |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2015
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5700985 |
Daftar Isi:
- Bioorganic & Heterocyclic Research Laboratory, Department of Applied Chemistry, Faculty of Engineering & Technology, M. J. P. Rohilkhand University, Bareilly-243 006, Uttar Pradesh, India E-mail : drnimjpru@rediffmail.com, niveditacdri2000@yahoo.com Manuscript received online 12 December 2014, accepted 04 March 2015 A simple, clean and convenient one-pot method has been developed for the synthesis of 4-substituted-3,4- dihydropyrimidinone by multicomponent condensation of ethyl acetoacetate, aromatic aldehydes and urea in basic medium in the presence of ethanol under refluxing conditions. The yield of all products is ≥ 90%. The synthesized compounds have been characterized on the basis of their spectroscopic data.