Synthesis and biological evaluation of quinoline-quinazolinones for antimicrobial and antileishmanial potential
| Main Authors: | Shweta Tiwari, Seema Kirar, Uttam Chand Banerjee, Neerupudi Kishore Babu, Sushma Singh, Inder Pal Singh |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5656647 |
Daftar Isi:
- Department of Natural Products, bDepartment of Pharmaceutical Technology Biotechnology, Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar-160 062, Punjab, India E-mail: ipsingh@niper.ac.in, ipsingh67@yahoo.com Manuscript received online 03 July 2020, accepted 30 July 2020 In an attempt to find a new class of antimicrobial and antileishmanial agents, a series of twenty-three quinoline-quinazolinones were prepared via reaction of 8-hydroxy/methoxyquinoline-2-carbaldehyde with various substituted aminobenzamides. These compounds were screened for their antimicrobial activity against Gram-positive bacteria (B. subtilis), Gram-negative bacteria (E. coli and P. putida) and fungus (C. viswanathii) and antileishmanial activity against promastigotes of L. donovani. Compound 28k exhibited highest activity against B. subtilis with an IC50 of 0.17±0.07 μM while compound 28j exhibited highest activity against promastigotes of L. donovani with an IC50 of 6±0.0 μM.