Synthesis, characterization, antibacterial evaluation and molecular docking study of 4-{[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]methyl}benzonitrile derivatives
| Main Authors: | Krishnaveni T. C., Sumana Y. Kotian, P. M. Abishad, K. Byrappa, K. M. Lokanatha Rai |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2020
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/5654983 |
Daftar Isi:
- Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysuru-570 005, Karnataka, India Department of Studies in Chemsitry, Center for Materials Science and Technology, University of Mysore, Manasagangotri, Mysuru-570 006, Karnataka, India Adichunchanagiri University, N.H. 75, B. G. Nagara, Mandya-571 481, Karnataka, India E-mail: sumanakotian@gmail.com, kmlrai@yahoo.com Manuscript received online 29 December 2019, revised and accepted 05 February 2020 Novel series of 1,3,4-oxadiazole derivatives were synthesized by the reaction between respective acid hydrazides with various aldehydes using chloramine-T (CAT). The structural characterization of compounds 7a-e were confirmed by LC-MS and 1H NMR, 13C NMR spectroscopy and they were subjected for biological evaluation and molecular docking studies. The synthesized compounds exhibited comparable activity with the standard.