Mixed ligand complexes of CuII with pyridoxal thiosemicarbazone and dipeptides: Synthesis, characterization, DNA binding, cleavage, antibacterial and docking studiesâ€
| Main Authors: | Ch. Venkata Ramana Reddy, Saritha Aduri, B. Sireesha |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5644936 |
Daftar Isi:
- Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Hyderabad-500 085, India E-mail: vrr9@yahoo.com Department of Chemistry, St. Francis College for Women, Hyderabad-500 016, India Department of Chemistry, Nizam College, Osmania University, Hyderabad-500 001, India Manuscript received online 28 November 2018, accepted 07 December 2018 Mixed ligand complexes of CuII of the type, [CuAL] where, A = pyridoxal thiosemicarbazone (PLTSC) and L = dipeptide viz. glycyl-glycine (gly-gly), glycyl-L-leucine (gly-leu), glycyl-L-tyrosine (gly-tyr) and glycyl-L-valine (gly-val), have been synthesized. They were characterized by elemental analyses, LC-MS, FTIR, UV-Vis and ESR studies, thermal analysis, molar conductance and magnetic susceptibility measurements. The ligand, A is coordinated through O,N,S donor atoms while, L is coordinated through the O,N,N donor atoms. However, in the complexes [Cu(PLTSC)(gly-leu)(H2O)] and [Cu(PLTSC)(gly-tyr)(H2O)], the PLTSC is coordinated only through O,N donor atoms. The interaction of the complexes with calf thymus DNA (CT-DNA) was investigated by UV-Vis absorption and fluorescence emission spectroscopy and also by viscosity measurements, which suggested intercalative mode of binding between the complexes and CT-DNA. The mode of DNA binding was further analyzed by docking studies, which supports intercalative binding. The complexes demonstrate excellent nuclease activity on super coiled plasmid pBR322 DNA in the studies by agarose gel electrophoresis. The metal complexes also exhibit moderate inhibition activity against Gram-positive bacteria.