Role of Cassia angustifolia in the Treatment of COVID-19 – In Silico Activity of Emodin against SARS-CoV-2 Spike Protein
| Main Authors: | Shaista Aslam, Rana Khurram Aftab, Ahmad Tariq, Avais Ahmad, Musarrat Ijaz, Noor e Hira |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2021
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5558615 |
Daftar Isi:
- ABSTRACT Background: Coronavirus epidemic has affected wide pulverization throughout the world. There is plenty of data and falsehood via online media with respect to medications and treatment for it. One of the viral advice nowadays is the use of Cassia angustifolia (Senna Makki). Methodology: This was an in-silico study to evaluate the efficacy of phytoconstituents of Senna against viral spike protein. Results: After docking several phytoconstituents of Senna using AutoDock 4, Emodin was found to best bind with the viral spike protein. Conclusion: Emodin shows great binding capacity with the SARS-CoronaV-2 spike protein and it has feasible pharmacokinetic properties to be used as a drug. Thus, we can infer that Emodin might be helpful for the management of COVID-19. Additional studies and trials are required to assess their actions. Keywords: COVID-19, Cassia angustifolia, Senna Makki, In silico