The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation
| Main Authors: | Pancaro, Alessia, Szymonik, Michal, Georgiou, Panagiotis G., Baker, Alexander N., Walker, Marc, Adriaensens, Peter, Hendrix, Jelle, Gibson, Matthew I., Nelissen, Inge |
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| Format: | Proceeding poster Journal |
| Bahasa: | eng |
| Terbitan: |
, 2021
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5499794 |
Daftar Isi:
- The localised surface plasmon resonance (LSPR) peak of gold nanorods (GNRs) is located in the near-infrared optical window and is sensitive to local binding events, enabling label-free detection of biomarkers in complex biological fluids. Glycan-binding proteins, called lectins, play a key role in many biological processes. To enable LSPR-based biosensing, the nanoparticles must be decorated with recognition units tethered to the surface by a ligand. We studied the sensing performance of GNRs coated with galactosamine-modified polymeric linkers for the detection of the lectin soybean agglutinin (SBA), used as a model analyte.