Anti-aging properties of metformin
| Main Authors: | Łopuszyńska, Anna, Pawlicki, Mateusz, Kozioł, Magdalena, Krasa, Aleksandra, Piekarska, Ewa, Piecewicz-Szczęsna, Halina |
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| Format: | Article Journal |
| Terbitan: |
, 2021
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| Online Access: |
https://zenodo.org/record/5418547 |
Daftar Isi:
- Łopuszyńska Anna, Pawlicki Mateusz, Kozioł Magdalena, Krasa Aleksandra, Piekarska Ewa, Piecewicz-Szczęsna Halina. Anti-aging properties of metformin. Journal of Education, Health and Sport. 2021;11(9):37-42. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.005 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.005 https://zenodo.org/record/5418547 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.08.2021. Revised: 25.08.2021. Accepted: 02.09.2021. ANTI-AGING PROPERTIES OF METFORMIN Anna Łopuszyńska1, Mateusz Pawlicki1, Magdalena Kozioł1, Aleksandra Krasa1, Ewa Piekarska1, Halina Piecewicz-Szczęsna2 1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland Corresponding author: Anna Łopuszyńska, lopuszynskaania@gmail.com ORCID ID: Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, lopuszynskaania@gmail.com Mateusz Pawlicki https//orcid.org/0000-0001-8318-6573, pawlak32@gmail.com Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, magdalena.koziol@icloud.com Aleksandra Krasa https://orcid.org/0000-0002-0733-202X, ola.AK62@gmail.com Ewa Piekarska https://orcid.org/0000-0002-4954-379X, piekarskaewaa@gmail.com Dr n. med. Halina Piecewicz-Szczęsna https://orcid.org/0000-0002-0573-7226, halpiec@gmail.com Abstract Introduction: Life expectancy of human population is being constantly prolonged, hence there is a lot of research into drug that will prevent the effects of aging. There are many reports that metformin, which is a drug used in type 2 diabetes, has anti-aging effects. It belongs to the group of biguanides and has been used since the 1950s. It is a relatively safe, cheap and effective drug, which makes it a promising subject for many studies. The purpose of this review is to present the latest developments in this field. Material and methods: PubMed scientific base was searched using following keywords: metformin, aging, anti-aging, in years 2017-2021. Results: Numerous studies show that metformin has an impact on aging through the nutrient pathway, AMPK signaling pathway, and its effects on reactive oxygen species. In addition, it has an anti-cancer effect, inhibiting, among others, rectal cancer cells and p53 mutant colon cancer. Research in rodents has shown that this drug has anti-aging effects on many organs, including the CNS, ovaries, prostate, heart muscle and skin. Conclusions: Metformin, which is the most commonly used oral drug in type 2 diabetes, has many other mechanisms of action. Its anti-aging effect works on many organs in our bodies, which gives hope to find an anti-aging substance. However, multicentre, randomized trials are needed to determine the exact anti-aging dose, its possible side effects, and effects on various organisms. Key words: metformin, anti-aging, aging