Prevalence of Extended-Spectrum β-Lactamases Producing Klebsiella pneumoniae Isolates: A Case from Tertiary Care Hospital, South India
| Main Authors: | Rangnekar Aseem, Mallaya Shrikara, Shenoy Shalini, Gupta Shefali |
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| Format: | Book publication-section Journal |
| Terbitan: |
Book Publisher International
, 2021
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5081414 |
Daftar Isi:
- Background: Klebsiella's significance in the growing number of gram-negative aerobic bacillary nosocomial infections in the United States and India. Antimicrobial resistance is on the rise in the current antibiotic period, which is a major source of concern. Multidrug-resistant species such as Klebsiella pneumoniae are one of the most common causes of sepsis and infection-related deaths. Aim: This research used phenotypic methods to assess the prevalence of ESBL-producing Klebsiella in different clinical specimens. Materials and Methods: The existence of Extended Spectrum—lactamases (ESBLs) in samples received over a two-year span was determined phenotypically in a prospective laboratory-based analysis. A total of 7644 gram negative bacterial isolates were recovered from a total of 16526 clinical specimens received in the microbiology laboratory, over the two year period. Among the 2497 isolates of Klebsiella, 1157 isolates were ESBL positive (46%). Conclusion: The infections caused by drug-resistant Klebsiella that produce ESBL are difficult to treat, and they can be fatal. In all healthcare settings, a strong and prompt implementation of an effective antibiotic policy and rational use of antibiotics is needed.