Data from: Inhibition decorrelates visual feature representations in the inner retina
| Main Authors: | Franke, Katrin, Berens, Philipp, Schubert, Timm, Bethge, Matthias, Euler, Thomas, Baden, Tom |
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| Format: | info dataset Journal |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/5052889 |
Daftar Isi:
- The retina extracts visual features for transmission to the brain. Different types of bipolar cell split the photoreceptor input into parallel channels and provide the excitatory drive for downstream visual circuits. Mouse bipolar cell types have been described at great anatomical and genetic detail, but a similarly deep understanding of their functional diversity is lacking. Here, by imaging light-driven glutamate release from more than 13,000 bipolar cell axon terminals in the intact retina, we show that bipolar cell functional diversity is generated by the interplay of dendritic excitatory inputs and axonal inhibitory inputs. The resulting centre and surround components of bipolar cell receptive fields interact to decorrelate bipolar cell output in the spatial and temporal domains. Our findings highlight the importance of inhibitory circuits in generating functionally diverse excitatory pathways and suggest that decorrelation of parallel visual pathways begins as early as the second synapse of the mouse visual system.
- FrankeEtAl_BCs_2017_main This data file contains the main dataset used for the clustering shown in Fig. 2 of the paper. Details about the different variables are available in the attached pdf. FrankeEtAl_BCs_2017_v1.mat FrankeEtAl_BCs_2017_chirp_byrepeat This file contains the individual repeats in response to the chirp stimulus. For details, see pdf. FrankeEtAl_BCs_2017_step_byrepeat This file contains the individual repeats in response to the step stimulus. For details, see pdf. FrankeEtAl_BCs_2017_noise_raw This file contains the response traces for the dense noise stimulus used for mapping RFs. For details, see pdf. FrankeEtAl_BCs_2017_cs_update This file contains the response traces to the center-surround noise from Fig. 5. For details, see pdf. FrankeEtAl_BCs_2017_drugdata This file contains the responses to the same stimuli as in the main dataset under application of different drugs as for the analysis shown in Fig. 4. For details, see pdf.