Research on Synthesis and Anti Convulsant Activity of Novel Oxadiazole Substituted Phenothiazine Derivatives
| Main Authors: | N. S. Dighe, A. A. Bankar, D. S. Musmade, S. A. Nirmal |
|---|---|
| Format: | Book publication-section Journal |
| Terbitan: |
Book Publisher International
, 2021
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4776187 |
Daftar Isi:
- The purpose of this research is directed towards the synthesis and evaluation of novel agents for the treatment of a variety of neurological disorders. In the past, the phenothiazine nucleus has been thoroughly investigated for various biological activities. The oxadiazole substituted phenothiazine has piqued interest as a potential treatment for a variety of neurological disorders. In light of these findings, researchers attempted to synthesise substituted phenothiazine and test them for anticonvulsant activity. Strychnine and 4-aminopyridine mediated models were used to test the anti-convulsant efficacy of synthesised compounds. These compounds can be used for ligand based drug designing purpose by which exact molecular mechanism responsible for showing anti-convulsant effect can be explored in future.