Appointing the Pharmacological studies Schiff base from hydrazine derivative and L-Histidine as a co-ligand with complexes: cytotoxic, antimicrobial and DNA interaction efficacy
| Main Authors: | Eman Mutar Atiyah, Eiman AA Abass, Rehab Kadhim Raheem Al-shemary |
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| Format: | Article Journal |
| Terbitan: |
, 2021
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4639538 |
Daftar Isi:
- A total of four new metal complexes bearing L-Histidine as a co-ligand and Schiff base based-hydrazine as primary were prepared and assayed by mass, (NMR) resonance of nuclear magnetic, (FT‐IR) Fourier transform infrared, (UV‐Vis) visible of ultraviolet, and analysis of elemental. From the spectral study, all the mixed metal complexes acquired as a monomeric system and the center of the metal moieties are six-coordinated with octahedral structure for [M(CNO)(His)2]complexes where M= Co(II), Ni(II), Cu(II) and Zn(II). The cytotoxic activity of the ligand and its metal complexes was screened after adequate affirmation from the seniority DNA linking searches. The metal complexes might link to CT-DNA through intercalation linking structure. The activities of DNA cleavage for the complexes with pBR322 DNA were inspected by electrophoresis of gel. The prepared complexes were established to enhance the cleavage of pBR322 DNA from the supercoiled form (I) to the open circular form (II) in the existence of (H2O2) as oxidizing. In vitro the chemosusceptibility of the prepared complexes reference that the Cu(II) complex is efficient with the chosen cell lines of human tumor, and the order of in vitro anticancer efficacies is steady with the affinities of DNA-linking and complex of Cu(II) shows very less toxicity.