Amyloid-beta42/Neurogranin Ratio as a Potential Index for Cognitive Impairment in Parkinson's Disease
| Main Authors: | Sancesario, Giulia Maria, Di Lazzaro, Giulia, Alwardat, Mohammad, Biticchi, Benedetta, Basile, Valerio, Salimei, Chiara, Colona, Vito Luigi, Sinibaldi Salimei, Paola, Bernardini, Sergio, Mercuri, Nicola Biagio, Pisani, Antonio, Schirinzi, Tommaso |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4585593 |
Daftar Isi:
- Background: Synaptopathy is critical in pathophysiology of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of neurogranin (NG) and amyloid-_42 (A_42) are considered markers of synaptic dysfunction in neurodegenerative diseases. Objective: To evaluate the CSF synaptopathy-related biomarkers, especially the novel A_42/NG ratio, in PD, establishing possible associations with cognitive level and other clinical parameters. Methods: Levels of NG, A_42, amyloid-_40, total and phosphorylated tau, and A_42/NG ratio were measured in 30 PD patients and 30 controls and correlated with cognitive and motor parameters. The accuracy in distinguishing the cognitive status was determined. Results:NGandA_42 were significantly reduced in PD, with higherNGlevels in patients with worse cognition. TheA_42/NG ratio showed a direct correlation with Mini-Mental State Examination, independently from age and sex, and differentiated cognitively impaired patients with 92% sensitivity and 71.4% specificity, accuracy higher than NG alone. No correlations resulted with motor disturbances or therapy. Conclusions: The novel A_42/NG ratio couples either presynaptic or postsynaptic markers of synaptic dysfunction, representing a potential global index of synaptopathy, useful to track cognitive functions in PD.