Multifocal ERG Recording In Patient On Hydroxychloroquine Therapy
| Main Author: | Bonti Bora |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2012
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/4468653 |
Daftar Isi:
- Introduction: Multifocal electroretinography (mfERG) is a new technique that allows analysis of local function of Retina. Hydroxychloroquine is a drug which has dose dependent systemic toxicity including significant visual disturbances & loss of vision. The use of mfERG for evaluating Hydroxychloroquine retinopathy appeared to detect retinal physiological changes earlier than other testing modalities and may enable documentation of preclinical stage of Hydroxychloroquine retinopathy. Method: 80 patients taking HCQS therapy are randomly selected.Result: Out of these asymptomatic patients electrophysiological abnormalities in two and three dimensional study were seen in 13 patients. Para central depression was found in 17 eyes while generalized depression was found in 8 eyes. In one eye normal recording was found. The study has got external validity or generalizability because the effect of drug on retina will be same in all parts of the country though affect of confounder bias i.e. the other cause associated with defect in mfERG may be there, so it is applicable in prevention of further effect on retina. Conclusion: mfERG has got high sensitivity & specificity in diagnosing early retinal defect.