Analysis of level of antioxidants in cancer patients after receiving radiotherapy
| Main Authors: | Muhammad Ali, Khair Ul Inam, Mir Ahmad |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4446446 |
Daftar Isi:
- Introduction: The involvement of the reactive oxygen species (ROS) is well documented in various disease processes, including cancers. Under normal circumstances, the redox status of cells is maintained by a balance between ROS production and its sequestration by antioxidants. Aims and objectives: The main objective of the study is to analyse the level of antioxidants in cancer patients after receiving radiotherapy.Material and methods: This cross sectional study was conducted in DHQ Hospital, Shangla during March 2018 to December 2018. This study was done with the permission of ethical committee of hospital. The data was collected from 100 cancer patients of both genders. We include breast cancer patients who receives radiotherapy. Those patients who receiving radiotherapy were selected to study the antioxidant status in the diseased condition.Results: The data present in this table explains the levels of MDA in breast cancer females. The data suggest that lipid peroxidation is increases in breast cancer. The reason is due to high damage of membrane and lipid peroxidation poducts. No significant association was observed between breast cancer risk and the highest quartiles of these antioxidant intakes from dietary sources compared with the lowest quartiles of intake, either for premenopausal or for postmenopausal breast cancer.Conclusion: It is concluded that antioxidants such as beta-carotene, vitamin C, vitamin E and zinc may reduce the risk of breast cancer. By reducing oxidative stress, lipid peroxidation, antioxidants counteract the effects of chemotherapy-induced oxidative stress on the cell cycle and enhance the cytotoxicity of antineoplastic agents.