Effect of ceramides in Streptococcus agalactiae infection throughout bacterial meningitis
| Main Authors: | Dr. Ifra Shafique, Dr. Zunaira Khalid, Dr. Saba Ahmad |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4436296 |
Daftar Isi:
- Ceramide platforms are clusters of ceramides on a cell surface that function to cluster receptors. These platforms contribute to signal transduction by amplifying potential signals and promoting the localization of signaling molecules. Previously it has been shown that another important meningeal pathogen, Neisseria meningitidis, promotes ceramide platforms on human BMEC (hBMEC) and this promotes bacterial invasion. We hypothesized that a similar mechanism may be employed by GBS. Bacterial meningitis a serious infection of the central nervous system (CNS) and represents a significant amount of morbidity and mortality. Streptococcus agalactiae (Group B Streptococcus, GBS) is a major contributor to neonatal meningitis. These data suggest that ceramide platforms may contribute to GBS activation and invasion of hBMEC during bacterial interaction with BBB endothelium. Taken together these findings suggest that ceramide platforms are critical for promoting interactions between bacterial pathogens and the BBB. Future studies seek to further characterize these platforms and identify specific host receptors that are critical for GBS-BBB interaction.