Incidence of Alzheimer's Disease in Type II Diabetes Mellitus and Its associated Risk Factors of Development of Dementia and Cognitive Decline
| Main Authors: | Hafiz Abdul Rauf, Nadia Saleem, Ammar Raza Bajwa, Hafiz Muhammad Rizwan Ali |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4420137 |
Daftar Isi:
- Objective:The purpose of this study is to explore the major risk factors for dementia and cognitive impairment in Alzheimer's disease after diabetes mellitus and to differentiate the Alzheimer's diseaserisk development in people with and without D.M. Background:Type 2 diabetes mellitus (T2DM) may increase Alzheimer's disease (AD) specifically associated dementia risk through various biological pathways, but the relationship between DM and AD development remains unclear. Place and Duration: The study was conducted in Endocrinology Department of Nishter Hospital,Multan for a period of 2 years from February 2012 to March 2014. Methods:The reference test was conducted from February 2012 to March 2014 to determine the prevalence of common dementia in 401 cases of both sexes over 50 years of age. In all these cases Mini-Mental State Examination (MMSE) was performed. Blood glucose levels were randomly determined at each visit; A complete examination of all participants was performed clinically. Results:In this study we came to the conclusion that with increases duration of diabetes, age and related conditions,over weight dementia increases. with diabetesDementia increases and chi-square tests support the conclusions." The value of the statistic chi-square test calculated, corresponding to p, was 130.26 with a score of 9 .It was also considered that obesity diabetic patients had a greater chances of AD development, and participants with diabetesat theborderline were also at greater risk of AD development. Conclusion:This study demonstrated that one of the greater risk factors that will increase AD risk is diabetes mellitus type 2; However, obesity may cause pathological problems in participants with Alzheimer's disease and cognitive and dementia decline markedly marked with other factors such as lifestyle and aging.