Therapeutic potential of active metabolites from Lactobacillus rhamnosus and mare's milk in the treatment of dybiosis
| Main Authors: | Samat Kozhakhmetov, Dmitriy Babenko, Altynay Tuyakova, Madiyar Nurgaziyev, Ayaulym Nurgozhina, Nurislam Muhanbetganov, Laura Chulenbayeva, Shynggys Sergazy, Alexandr Gulyayev, Mohamad Aljofan, Almagul Kushugulova |
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| Format: | Article Journal |
| Terbitan: |
, 2020
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| Online Access: |
https://zenodo.org/record/4221657 |
Daftar Isi:
- Ulcerative colitis is an inflammatory bowel disease that forms ulcerations in the mucous membrane of the colon and rectum, in which gut microbiota plays pivotal role in its pathogenesis. Agents modulating microbial dysbiosis caused by colitis can help in the remission of this disease. The current study describes potential therapeutic effects of active metabolites from Lactobacillus rhamnosus and mare’s milk have potential therapeutic values on the intestinal microbiota and pro-inflammatory cytokines. The analysis of the V1-V3 16S rDNA site revealed significant changes in the intestinal microbiome composition before and after treatment in the treated group compared to the positive control group that was treated with 5-ASA. So, the effect of the study product on Dextran Sulfate Sodium induced dysbiosis was shown to be more potent than the positive control, 5-ASA. The level of pro-inflammatory cytokines also decreased under the influence of a biological product.Ulcerative colitis is an inflammatory bowel disease that forms ulcerations in the mucous membrane of the colon and rectum, in which gut microbiota plays pivotal role in its pathogenesis. Agents modulating microbial dysbiosis caused by colitis can help in the remission of this disease. The current study describes potential therapeutic effects of active metabolites from Lactobacillus rhamnosus and mare’s milk have potential therapeutic values on the intestinal microbiota and pro-inflammatory cytokines. The analysis of the V1-V3 16S rDNA site revealed significant changes in the intestinal microbiome composition before and after treatment in the treated group compared to the positive control group that was treated with 5-ASA. So, the effect of the study product on Dextran Sulfate Sodium induced dysbiosis was shown to be more potent than the positive control, 5-ASA. The level of pro-inflammatory cytokines also decreased under the influence of a biological product.