Efficacy of the N-acetylglucosamine in experimental therapy of chronic kidney disease
| Main Authors: | Shebeko, Sergii, Zupanets, Igor, Otrishko, Inna |
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| Format: | Article Journal |
| Terbitan: |
Bulgarian Pharmaceutical Scientific Society
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4164613 |
Daftar Isi:
- The efficacy of N-acetylglucosamine in rats with chronic kidney disease is described in this article. The results of the study show that N-acetylglucosamine significantly increased (p<0.05) the excretion of nitrogen compounds (creatinine by 100.4% and urea by 46.6%) and as a result de-creased the level of azotemia. The intensity of free radical oxidation was significantly decreased (p<0.05) (blood conjugated dienes by 32.9%, blood thiobarbituric acid reactive substances – by 14.1%, kidney conjugated dienes – by 40.1% and kidney thiobarbituric acid reactive substances – by 26.3%) and the balance of kidney antioxidant system was restored. N-acetylglucosamine was significantly superior (p<0.05) to comparator quercetin in renal excretory function and nitro-gen metabolism by the most of indicators and was not inferior to the influence on the free radical oxidation and kidney oxidative stress. Thus, N-acetylglucosamine is advisable to further experimental studies at i.m. administration as a chronic kidney disease treatment.