Biogenesis of Medium-Chain-Length Polyhydroxyalkanoates
| Main Authors: | Kniewel, Ryan, Revelles Lopez, Olga, Prieto, Auxiliadora |
|---|---|
| Format: | Book publication-section |
| Terbitan: |
Springer International Publishing AG 2017
, 2017
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4110764 |
Daftar Isi:
- Medium-chain-length polyhydroxyalkanoates (mcl-PHA) are biotechnologically useful natural products found in many bacteria. This biopolymer functions as a carbon and energy storage reservoir in cells but has physical and mechanical properties that make it a promising bioplastic with applications ranging from adhesives to medical implants. Therefore, there is much interest in understanding the biology of mcl-PHA synthesis and metabolism. Increased knowledge of PHA biology serves as a foundation for the bioengineering of PHA and its eventual use as a biologically derived product. This chapter covers the state of knowledge on mcl-PHA, including its synthesis and its central role in cellular metabolism. Moreover, this chapter discusses methods for bioengineering mcl-PHA production in bacteria as well as synthetic biology methods for its study and production in the natural mcl-PHA producer, Pseudomonas putida.