Expression of the VEGF marker in endometrial cells in hyperplastic processes
| Main Author: | Chumak, Z. V. |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2020
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| Online Access: |
https://zenodo.org/record/4110745 |
Daftar Isi:
- Chumak Z. V. Expression of the VEGF marker in endometrial cells in hyperplastic processes. Journal of Education, Health and Sport. 2020;10(10):81-89. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.10.008 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.10.008 https://zenodo.org/record/4110745 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 09.09.2020. Revised: 22.09.2020. Accepted: 20.10.2020. EXPRESSION OF THE VEGF MARKER IN ENDOMETRIAL CELLS IN HYPERPLASTIC PROCESSES Z. V. Chumak Odessa National Medical University; City Center for Menopause, Odessa Abstract Hormone-dependent diseases related to preproliferative processes and endometrial cancer have a clear tendency to increase and rejuvenate. The purpose: to study the expression of VEGF marker in endometrial cells under physiological, hyperplastic, atypical conditions in women’s different age periods. 2196 pathomorphological findings of endometrial tissue samples in women with clinical manifestations requiring surgical treatment have been analyzed. VEGF expression was performed in endometrial tissue samples of 458 women of late reproductive, perimenopausal and postmenopausal age. Each age category is characterized by its morphofunctional features of the endometrial tissue. Results. The frequency of detection of hyperplastic processes, atypical hyperplasia and adenocarcinoma indicates that starting from the period after 40 y.o. the mechanisms of initiation and development of factors in the system of self-sufficiency in mitogenic stimuli, constant proliferation and insensitivity to antimytogenic signals", loss of “Hayflick’s limit”, reduced ability to apoptosis, propensity to immortalization take place. Conclusion: The expression of VEGF concentration in endometrial tissue as an inducer of angiogenesis is increased in hyperplastic processes. Significant growth is observed in the processes of atypical hyperplasia, especially in the postmenopausal period. Determination of VEGF concentration in endometrial proliferative processes can be a promising marker for diagnosing the risk of atypical conditions and their prognosis. Research in this direction is quite relevant. Key words: endometrial hyperplasia; atypical endometrial hyperplasia; angiogenesis; VEGF; malignancy