Pseudo-five-component condensation for the diversity-oriented synthesis of novel indoles and quinolines containing pseudo-peptides (tricarboxamides)
| Main Authors: | Heravi; Majid M, Shiri, M., Momahed Heravi, M., Zadsirjan, V., Najatinezhad Arani, A., Shintre, S.A., Koorbanally, N.A. |
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| Format: | Article |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4052265 |
Daftar Isi:
- A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two C-N bonds, and one C=O bond. Remarkably, three peptide bonds were formed through a domino sequence including Knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. Particularly, a number of structurally remarkable and pharmacologically significant products were provided in excellent yields.