Prevalence and disease severity of multiple respiratory pathogens among children with severe lower respiratory tract infection
| Main Authors: | Lee Jeffrey Soon-Yit, Chua Tiing-Tiing, Ting Jakie, Wong See-Chang, Chieng Chae-Hee, Toh Teck-Hock |
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| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4028012 |
Daftar Isi:
- Objectives To determine the prevalence of multiple respiratory pathogens in children with severe lower respiratory tract infection (LRTI), and compare disease severity, duration of hospitalization and ventilation between those with and without multiple respiratory pathogens. Methods This was a cross-sectional, case record review of children aged between one month and 12 years, with severe LRTI in 2019. Case records were reviewed, and data extracted manually using a standard case report form. Statistical Analysis Prevalence were expressed as numbers and percentages. Mean (or median) were compared using independent t-test (or Mann-Whitney test). Proportions were compared with chi-square test or Fisher exact test. Results Sixty-four children were recruited, with median age of 9.5 months (IQR 17.25 months) and 37 (57.8%) children were male. Forty-six children (71.9%) had multiple respiratory pathogens, with 41 (89.1%) of them having both virus and bacteria. Respiratory syncytial virus (RSV) [RSV A (n=10, 15.6%) and RSV B (n=14, 21.9%)] being the commonest virus detected and children with RSV were significantly younger (7.0 months vs. 15.0 months, P=0.007). The most prevalent bacteria detected was Haemophilus influenzae (n=38, 59.4%), followed by Streptococcus pneumoniae (n=29, 45.3%). Children with multiple respiratory pathogens required higher FiO2 (mean difference 12.3%, 95% CI: 2.5, 25.9, P=0.014). Children with multiple respiratory pathogens were also more likely to require inotropes, have longer ventilation and hospitalization days, although not statistically significant. Conclusion Multiple respiratory pathogens was common in children and associated with a higher FiO2 requirement, and a statistically non-significant risk of longer hospitalization, longer duration of ventilation days, and a higher need for inotropes.