Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM
| Main Authors: | van der Aart, Jasper, van der Doef, Thalia F, Horstman, Paul, Huisman, Marc C, Schuit, Robert C, van Lingen, Arthur, Windhorst, Albert D, van Berckel, Bart,NM, Lammerstma, Adriaan A |
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| Format: | Article |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/400829 |
Daftar Isi:
- The methylguanadine derivative [11C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [11C]GMOM radiation dose in healthy humans. Methods: Following [11C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose. Results: Absorbed radiation doses in source organs ranged from 7.7 μGy·MBq-1 in the brain to 12.7 μGy·MBq-1 in the spleen. The effective dose (±SD) was 4.5 ± 0.5 μSv·MBq-1 Conclusion: The effective dose of [11C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.