Potential Interventions for SARS-CoV-2 Infections: Zinc Showing Promise
| Main Authors: | Brewer, Joseph, Brufsky, Adam |
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| Format: | info publication-preprint Journal |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4005057 |
Daftar Isi:
- Zn, in the presence of a Zn ionophore (such as HCQ), shows potent anti-viral activity in vitro against coronaviruses such as SARS-CoV. This activity likely extends to SARS-CoV-2 and may potentially involve at least three different antiviral mechanisms. Zn deficiency may be associated with COVID-19 severity during infection and increase the risk of severity when present before infection. Maintaining normal Zn levels may help prevent illness severity in COVID-19 infection. An additional mechanism of HCQ activity in COVID-19 patients may be the Zn ionophore effect. Supplemental Zn has been shown to act together with HCQ (presumably acting as a Zn ionophore) in clinical studies of COVID-19 patients: demonstrating decrease hospitalizations, increased discharge in treated inpatients and decreased mortality. The elemental Zn dose in these studies was 50 – 100 mg per day (as Zn sulfate). Zn should be considered as an add-on to HCQ treatment regimens (at least 50mg elemental Zn equivalent, based on above studies). Zn could potentially allow for short courses and low doses of HCQ, yet remain a highly effective regimen.