Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring
| Main Authors: | Zielińska, Martyna Maria, Zarankiewicz, Natalia, Kuchnicka, Aleksandra, Kosz, Katarzyna, Ciseł, Bogumiła |
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| Format: | Article |
| Terbitan: |
, 2020
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| Online Access: |
https://zenodo.org/record/3992401 |
Daftar Isi:
- Zielińska Martyna, Zarankiewicz Natalia, Kuchnicka Aleksandra, Kosz Katarzyna, Ciseł Bogumiła. Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring. Journal of Education, Health and Sport. 2020;10(8):251‐259. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.029 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.029 https://zenodo.org/record/3992401 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2020. Revised: 05.08.2020. Accepted: 20.08.2020. Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring Martyna Maria Zielińska, Natalia Zarankiewicz, Aleksandra Kuchnicka, Katarzyna Kosz, Bogumiła Ciseł Martyna Maria Zielińska ORCID iD https://orcid.org/0000-0001-8886-8274 Affiliation Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin Country Poland Bio Statement — Principal contact for editorial correspondence. Natalia Zarankiewicz ORCID iD https://orcid.org/0000-0001-9203-3376 Affiliation Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin Country Poland Bio Statement — Aleksandra Kuchnicka ORCID iD https://orcid.org/0000-0001-8481-7592 Affiliation Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin Country Poland Bio Statement — Katarzyna Kosz ORCID iD https://orcid.org/0000-0001-6848-0598 Affiliation Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin Country Poland Bio Statement — Bogumiła Ciseł ORCID iD https://orcid.org/0000-0001-6970-1698 Affiliation Oncological Surgery Department, Independent Public Teaching Hospital No. 1, Lublin; Medical University, Lublin Country Poland Bio Statement Assistant/MD, PhD (Department of Surgical Oncology) ABSTRACT Introduction: Pregnancy-associated breast cancer (PABC) is the most common malignancy in pregnant women with an incidence of 1 in 3-10 thousand pregnancies. It is mostly defined as breast cancer diagnosed during pregnancy or within 1 year postpartum. The number of PABCs is going to raise due to the trend of delaying childbearing. Purpose: This review summarizes data on the occurrence and characteristics of PABC. The analysis comprises diagnosis and proper treatment of BC during pregnancy. Prognosis of women and their offspring are emphasized. Material and methods: The review is based on publications mainly from 2010 to 2019 and 5 articles from 1994-2008 collected on the PubMed. Results: The sensitivity of breast ultrasonography (USG) in pregnancy is 70-100% and it is considered as safe for the fetus. Staging evaluation in pregnant women consists of chest x-ray, liver USG and non-contrast bone MRI. 71-88% of PABCs are invasive ductal carcinomas. Treatment consists of breast surgery regardless of time and optionally, chemotherapy from the 2nd trimester. Radiotherapy, tamoxifen and trastuzumab are contraindicated in PABC. Therapeutic abortion does not improve oncological outcome. Overall prognosis is similar for both pregnant and non-pregnant patients with similar type and stage of BC. The rate of congenital malformations is 1,3% for both children of PABC patients treated with chemotherapy and born from women without chemotherapeutic treatment. The most frequent obstetrical complication of PABC treatment is preterm delivery. Conclusions: Pregnancy does not impact oncologic outcome, if the treatment is appropriate. PABC patients have survival rates consistent with the stage of disease. Proper treatment of PABC does not increase the risk of congenital malformations and is relatively safe for the fetus. Key words: pregnancy-associated breast cancer; breast cancer; prognosis; pregnancy; breast cancer treatment