Microwave Assisted Synthesis of Heterocycles Accompanied by Antimicrobial Screening
| Main Authors: | Prashant P. Chaudhari, Ravindra S. Dhivare, Shankarsing S. Rajput |
|---|---|
| Format: | Article |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3911291 |
Daftar Isi:
- Abstract A clean, efficient, and solvent-free method for the synthesis of Bis-chalcones and Pyrazoles was carried out with the help of microwave irradiations and neutral alumina. The novel class of Bischalcones and pyrazoles were comprehended by the treatment of N-phenyl succinimides with p-fluoro benzaldehyde. The cyclic imide on condensation with p-fluoro benzaldehyde furnished a series of bis chalcones and further, they undergo cyclization with hydrazine hydrate to furnish pyrazoles. This condensation could make better and easier by a solvent-free mechanism with the help of microwave irradiations and neutral alumina. This method furnished various advantages, such as straight forward work-up procedure, environmentally benevolent, neutral condition, and high yield. All the synthesized moieties were characterized and interpreted for antimicrobial activities.