MRI guided magneto-chemotherapy with high magnetic moment iron oxide nanoparticles for cancer theranostics
| Main Authors: | Ashwini Bhagwanrao Salunkhe, Vishwajeet Khot, S. I. Patil, Syed A. M. Tofail, Joanna Bauer, Nanasaheb Thorat |
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| Other Authors: | Ashwini Salunkhe |
| Format: | Article Journal |
| Bahasa: | bah |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3698173 |
Daftar Isi:
- To elevate and monitor the temperature of tumor using magnetic nanoparticles (MNPs) still present challenge in magnetic hyperthermia therapy. The efficient heating of tumor volume can be achieved by preparing MNPs with high magnetization values. The next generation approach to magnetic resonance image (MRI)-guided magneto-chemotherapy of cancer based on high magnetic moment iron oxide nanoparticles is proposed. The proof of concept is validated by cellular MRI experiments on breast cancer cells. To explore magneto-chemotherapy, high magnetic moment iron oxide (Fe3O4) nanoparticles (NPs) are developed using base Diisopropylamine (DIPA) which plays dual role as reducing agent and surface stabilizer. Spherical NPs with ~ 12 nm size and high magnetization value of about 92 emu g-1 at room temperature are obtained by this unique method. High specific absorption rate value of ~717 wg-1 is obtained for Fe3O4 NPs in water at an alternating magnetic field of 20 kAm-1 and frequency of 267 KHz, which is attributed to high magnetization value. Magneto-polymeric micelle structure is formed by using Pluronic F127, anticancer drug Doxorubicin is conjugated in micelle by electrostatic interactions for magneto-chemotherapy. Finally, the magnetic resonance imaging (MRI) guided magneto-chemotherapy is achieved on breast cancer (MCF7) cells with overall ~ 96 % killing of cancer cells is achieved by 30 min of MCT.